FIGURE

Figure 1

ID

ZDB-FIG-260730-22

Publication

Zhang et al., 2026 - CFTR and ClC-3 Transport Fluoride Differently and Cause Dental Fluorosis in Different Ways

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Figure 1

DF cases and pedigree analysis of CFTR M470V variants. (A) Typical tooth characteristics of DF cases in the investigation. Note enamel discoloration and local defects in the affected teeth. (B) DF phenotype and rs213950 genotype in a four-generation DF family. The first and second generations lived with well water and the 3rd and 4th generations lived with tap water. The five members in the 3rd generation (III₂, III₄, III₅, III₆, and III₇) suffered from DF, although with the tap water. Numbers above the pedigree symbols indicate the individual IDs. A diagonal slash indicates a deceased individual. Black, dark gray, light gray, and white symbols represent severe, medium, mild, and unaffected dental fluorosis (DF), respectively. “N/A” indicates that the phenotype or genotype was not available.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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