FIGURE
Fig. 2
- ID
- ZDB-FIG-251229-54
- Publication
- Nguyen et al., 2025 - Functional divergence of zebrafish keap1 paralogs revealed by CRISPR/Cas9-mediated gene editing: a specialized role for keap1b in inflammation
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Fig. 2
Keap1 paralogs differentially regulate survival under oxidative stress. Survival curves of WT, nfe2l2a−/−, keap1a−/−, and keap1b−/− larvae exposed to 3 mM H2O2 for 48 h. Loss of either Keap1a or Keap1b confers significant protection against oxidative stress compared to wild-type. Conversely, loss of Nrf2a (nfe2l2a−/−) results in extreme hypersensitivity, confirming the essential protective role of this transcription factor. Data are representative results from n = 3 biological replicates. ****p < 0.0001 vs. control |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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