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Figure Caption
Fig. 2 Keap1 paralogs differentially regulate survival under oxidative stress. Survival curves of WT, nfe2l2a−/−, keap1a−/−, and keap1b−/− larvae exposed to 3 mM H2O2 for 48 h. Loss of either Keap1a or Keap1b confers significant protection against oxidative stress compared to wild-type. Conversely, loss of Nrf2a (nfe2l2a−/−) results in extreme hypersensitivity, confirming the essential protective role of this transcription factor. Data are representative results from n = 3 biological replicates. ****p < 0.0001 vs. control
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