FIGURE

Fig 5

ID

ZDB-FIG-250904-36

Publication

Farr et al., 2025 - A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

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Fig 5

Early heart development appears normal in pomp and psmd6 mutants.

A.-C. Dorsal views of ALPM labeled for myl7 in blue in 18 hpf embryos. Normal heart morphology: 6/6 pomp⁺^/⁺, 7/7 psmd6⁺^/⁺, 11/11 pomp^-/-, 8/8 psmd6^-/-. Scale bar = 100 μm. D.-F. Dorsal views of hearts labeled for myl7 in blue in 24 hpf larvae. Normal heart morphology: 8/8 pomp⁺^/⁺, 8/8 psmd6⁺^/⁺, 6/6 pomp^-/-, 10/10 psmd6^-/-. Scale bar = 100 μm. G.-I. Ventral views of hearts labeled with myl7:EGFP in 48 hpf embryos. Normal heart morphology: 13/16 pomp⁺^/⁺, 11/12 psmd6⁺^/⁺, 14/14 pomp^-/-, 11/12 psmd6^-/-. Scale bar = 50 μm. V, ventricle. A, atrium. J.-L. Ventral views of hearts labeled with myl7:EGFP in 72 hpf larvae. Normal heart morphology: 35/38 pomp⁺^/⁺, 22/24 psmd6⁺^/⁺, 39/45 pomp^-/-, 25/29 psmd6^-/-. All embryos were genotyped. Scale bar = 50 μm. V, ventricle. A, atrium.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomp^scm41/scm41; twu34Tg psmd6^scm40/scm40; twu34Tg
Observed In:	heart development
Stage Range:	14-19 somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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