FIGURE

Fig 8

ID

ZDB-FIG-250904-39

Publication

Farr et al., 2025 - A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

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Fig 8

Myocardial sarcomere and myofibril formation appear normal in pomp and psmd6 mutants.

A.-C. Ventral views of ventricles labeled with α-actinin (A-C) in 4 dpf larvae. Scale bar = 25 μm. D.-E. Magnified views of α-actinin stain. Encircled green lines illustrate sarcomere lengths, with corresponding measurements shown. Encircled magenta lines illustrate myofibril widths, with corresponding measurements shown. Scale bar = 10 μm. F.-G. Graphs showing (F) sarcomere length and (G) myofibril width measurements at 4 dpf. Each dot represents the average of 9-14 measurements (one per myofiber) from a single heart/larva. Bars represent mean +/- SEM. All animals were genotyped. N = 7 pomp⁺^/⁺ and psmd6⁺^/⁺. N = 8 pomp^-/- and psmd6^-/-. No significant differences were observed between wild-type and mutant hearts.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomp^scm41/scm41; twu34Tg psmd6^scm40/scm40; twu34Tg
Observed In:	myocardium cardiac myofibril myocardium sarcomere
Stage:	Day 4

Phenotype Detail

Acknowledgments

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