FIGURE

Fig. 3

ID

ZDB-FIG-250728-138

Publication

Kyrychenko et al., 2025 - Holoprosencephaly and cyclopia in bmp7b and bmpr1ba Crispant zebrafish

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Fig. 3

Analysis of gene expression patterns (wmish) in ANP domains in Crispants for bmp7b and controls (II). (embryos are presented in a lateral and in a dorsal view, the presumptive head is facing to the left, expression domains are encircled). The experimental design is as presented in Figure 3. (A–D) show expression of alcamb in controls (C, D) and Crispants (A, B). Please note the reduced expression in B in comparison to C (encircled). (E–H) show expression of zic2a in controls (G, H) and Crispants (E, F). Please note the extended width in between the lateral expression domains (arrows in F in comparison to arrows in H) as well as the reduced expression at the prospective posterior domain of the ANP (encircled in H, almost absent in F).

Expression Data

Genes:	alcamb zic2a
Fish:	WT WT + CRISPR3-bmp7b
Knockdown Reagent:	CRISPR3-bmp7b
Anatomical Term:	anterior neural keel
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + CRISPR3-bmp7b
Knockdown Reagent:	CRISPR3-bmp7b
Observed In:	anterior neural keel
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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