Gene

zic2a

ID
ZDB-GENE-000710-4
Name
zic family member 2 (odd-paired homolog, Drosophila), a
Symbol
zic2a Nomenclature History
Previous Names
  • zic2.1 (1)
  • zic2 (1)
  • cb851 (1)
  • fb26a03
  • wu:fb26a03
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; neural tube formation; and regulation of signal transduction. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Is expressed in several structures, including anterior neural keel; central nervous system; ectoderm; neural plate; and presumptive structure. Orthologous to human ZIC2 (Zic family member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zic2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
holoprosencephaly 5 Alliance Holoprosencephaly 5 609637
Associated With zic2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR041643 ZIC protein, zinc finger domain
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length ZIC protein, zinc finger domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q9IAT0 445
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations