PUBLICATION

Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes

Authors
Toyama, R., Gomez, D.M., Mana, M.D., and Dawid, I.B.
ID
ZDB-PUB-040402-7
Date
2004
Source
Gene expression patterns : GEP   4(3): 345-350 (Journal)
Registered Authors
Dawid, Igor B., Mana, Miyeko, Toyama, Reiko
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Central Nervous System/embryology
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/metabolism
  • Gene Duplication
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Somites/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Zinc Fingers/genetics
PubMed
15053986 Full text @ Gene Expr. Patterns
Abstract
The zinc finger motif forms a DNA binding domain that is found in a wide variety of proteins. Among them, the members of the zic gene family are highly conserved throughout metazoans. We report here the isolation of two new members of this gene family in zebrafish, zic2.2 and zic5, isolated during random screening for tissue-specific genes. Zic2.2 is closely related to the previously reported zic2 gene, which we propose to rename zic2.1; these two genes form a subfamily with other vertebrate zic2 genes. We compare here the expression patterns of zic2.1, zic2.2, and zic5. All three genes showed dynamic expression patterns starting after the initiation of zygotic transcription, predominantly in the developing neural tube. Compared to zic2.1, zic2.2 was expressed in a similar but distinct manner during early development, particularly in the retina and the forming somites. A zic2.2 ortholog has not been identified in other vertebrate species, suggesting that the zic2.1/zic2.2 pair resulted from a genome duplication event during the evolution of the zebrafish lineage.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes