ZFIN Person: Dawid, Igor B.

ZFIN ID: ZDB-PERS-960805-134

Dawid, Igor B.

Email:	idawid@mail.nih.gov
URL:	http://sdb.nichd.nih.gov/index.html
Affiliation:	Dawid Lab
Address:	Laboratory of Molecular Genetics National Institute of Child Health and Human Development National Institutes of Health Building 6B, Room 413 Bethesda, MD 20892 USA
Country:	United States
Phone:	(301) 496-4448
Fax:	(301) 496-0243
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Heffer, A., Marquart, G.D., Aquilina-Beck, A., Saleem, N., Burgess, H.A., Dawid, I.B. (2017) Generation and characterization of Kctd15 mutations in zebrafish. PLoS One. 12:e0189162

Won, M., Dawid, I.B. (2017) PCR artifact in testing for homologous recombination in genomic editing in zebrafish. PLoS One. 12:e0172802

Won, M., Ro, H., Dawid, I.B. (2015) Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas. Proceedings of the National Academy of Sciences of the United States of America. 112(40):12426-31

Komiya, Y., Mandrekar, N., Sato, A., Dawid, I.B., Habas, R. (2014) Custos controls β-catenin to regulate head development during vertebrate embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 111(36):13099-104

Kim, M.H., Rebbert, M.L., Ro, H., Won, M., Dawid, I.B. (2014) Cell adhesion in zebrafish embryos is modulated by march8. PLoS One. 9:e94873

Zarelli, V.E., and Dawid, I.B. (2013) The BTB-Containing Protein Kctd15 Is SUMOylated In Vivo. PLoS One. 8(9):e75016

Toyama, R., Kim, M.H., Rebbert, M.L., Gonzales, J., Burgess, H., and Dawid, I.B. (2013) Habenular commissure formation in zebrafish is regulated by the pineal gland-specific gene unc119c. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(9):1033-42

Zarelli, V.E., and Dawid, I.B. (2013) Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Proceedings of the National Academy of Sciences of the United States of America. 110(8):2870-2875

Coffey, C.M., Solleveld, P.A., Fang, J., Roberts, A.K., Hong, S.K., Dawid, I.B., Laverriere, C.E., and Glasgow, E. (2013) Novel oxytocin gene expression in the hindbrain is induced by alcohol exposure: transgenic zebrafish enable visualization of sensitive neurons. PLoS One. 8(1):e53991

Kawahara, A., Endo, S., and Dawid, I.B. (2012) Vap (Vascular Associated Protein): A novel factor involved in erythropoiesis and angiogenesis. Biochemical and Biophysical Research Communications. 421(2):367-374

Takesono, A., Moger, J., Faroq, S., Cartwright, E., Dawid, I.B., Wilson, S.W., and Kudoh, T. (2012) Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proceedings of the National Academy of Sciences of the United States of America. 109(9):3371-3376

Ro, H., and Dawid, I.B. (2011) Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. The EMBO journal. 30(14):2894-907

Hong, S.K., and Dawid, I.B. (2011) The transcriptional mediator component med12 is required for hindbrain boundary formation. PLoS One. 6(4):e19076

Dente, L., Gestri, G., Tsang, M., Kudoh, T., Wilson, S.W., Dawid, I.B., and Andreazzoli, M. (2011) Cloning and developmental expression of zebrafish pdzrn3. The International journal of developmental biology. 55(10-12):989-993

Ro, H., and Dawid, I.B. (2010) Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity. Biochemical and Biophysical Research Communications. 402(4):626-630

Aamar, E., and Dawid, I.B. (2010) Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2980-2988

Dutta, S., and Dawid, I.B. (2010) Kctd15 inhibits neural crest formation by attenuating Wnt/β-catenin signaling output. Development (Cambridge, England). 137(18):3013-3018

Znosko, W.A., Yu, S., Thomas, K., Molina, G.A., Li, C., Tsang, W., Dawid, I.B., Moon, A.M., and Tsang, M. (2010) Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Developmental Biology. 342(1):11-25

Cruz, C., Maegawa, S., Weinberg, E.S., Wilson, S.W., Dawid, I.B., and Kudoh, T. (2010) Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos. Proceedings of the National Academy of Sciences of the United States of America. 107(8):3564-3569

Swanhart, L.M., Takahashi, N., Jackson, R.L., Gibson, G.A., Watkins, S.C., Dawid, I.B., and Hukriede, N.A. (2010) Characterization of an lhx1a transgenic reporter in zebrafish. The International journal of developmental biology. 54(4):731-736

Ro, H., and Dawid, I.B. (2009) Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nature cell biology. 11(9):1121-1127

Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B. (2009) Transcriptome analysis of the zebrafish pineal gland. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1813-1826

Hong, S.K., and Dawid, I.B. (2009) FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Proceedings of the National Academy of Sciences of the United States of America. 106(7):2230-2235

Brown, J.D., Dutta, S., Bharti, K., Bonner, R.F., Munson, P.J., Dawid, I.B., Akhtar, A.L., Onojafe, I.F., Alur, R.P., Gross, J.M., Hejtmancik, J.F., Jiao, X., Chan, W.Y., and Brooks, B.P. (2009) Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1462-1467

Sperber, S.M., and Dawid, I.B. (2008) barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches. Developmental Biology. 321(1):101-110

Aamar, E., and Dawid, I.B. (2008) Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development. Developmental Biology. 318(2):335-346

Toyama, R., Rebbert, M.L., Dey, A., Ozato, K., and Dawid, I.B. (2008) Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(6):1636-1644

Hong, S.K., Tsang, M., and Dawid, I.B. (2008) The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development. PLoS One. 3(4):e2029

Zhao, H., Tanegashima, K., Ro, H., and Dawid, I.B. (2008) Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways. Development (Cambridge, England). 135(7):1283-1293

Hong, S.K., and Dawid, I.B. (2008) Alpha2 macroglobulin-like is essential for liver development in zebrafish. PLoS One. 3(11):e3736

Aamar, E., and Dawid, I.B. (2008) Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos. The International journal of developmental biology. 52(7):985-991

Hanaoka, R., Dawid, I.B., and Kawahara, A. (2007) Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO). DNA sequence : the journal of DNA sequencing and mapping. 18(1):54-60

Pugacheva, E.M., Kwon, Y.W., Hukriede, N.A., Pack, S., Flanagan, P.T., Ahn, J.C., Park, J.A., Choi, K.S., Kim, K.W., Loukinov, D., Dawid, I.B., and Lobanenkov, V.V. (2006) Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization. Gene. 375:26-36

Azuma, M., Toyama, R., Laver, E., and Dawid, I.B. (2006) Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system. The Journal of biological chemistry. 281(19):13309-13316

Hanaoka, R., Katayama, S., Dawid, I.B., and Kawahara, A. (2006) Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis. Genes to cells : devoted to molecular & cellular mechanisms. 11(3):293-303

Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18473-18478

Takahashi, N., and Dawid, I.B. (2005) Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Nucleic acids research. 33(13):e120

Kawahara, A., Che, Y.S., Hanaoka, R., Takeda, H., and Dawid, I.B. (2005) Zebrafish GADD45{beta} genes are involved in somite segmentation. Proceedings of the National Academy of Sciences of the United States of America. 102(2):361-366

Kudoh, T., Concha, M.L., Houart, C., Dawid, I.B., and Wilson, S.W. (2004) Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development (Cambridge, England). 131(15):3581-3592

Tsang, M., Maegawa, S., Kiang, A., Habas, R., Weinberg, E., and Dawid, I.B. (2004) A role for MKP3 in axial patterning of the zebrafish embryo. Development (Cambridge, England). 131(12):2769-2779

Appelbaum, L., Toyama, R., Dawid, I.B., Klein, D.C., Baler, R., and Gothilf, Y. (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Molecular endocrinology (Baltimore, Md.). 18(5):1210-1221

Toyama, R., Gomez, D.M., Mana, M.D., and Dawid, I.B. (2004) Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes. Gene expression patterns : GEP. 4(3):345-350

Preger, E., Ziv, I., Shabtay, A., Sher, I., Tsang, M., Dawid, I.B., Altuvia, Y., and Ron, D. (2004) Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proceedings of the National Academy of Sciences of the United States of America. 101(5):1229-1234

Piotrowski, T., Ahn, D.-G., Schilling, T.F., Nair, S., Ruvinsky, I., Geisler, R., Rauch, G.-J., Haffter, P., Zon, L.I., Zhou, Y., Foott, H., Dawid, I.B., and Ho, R.K. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (Cambridge, England). 130(20):5043-5052

Solomon, K.S., Kudoh, T., Dawid, I.B., and Fritz, A. (2003) Zebrafish foxi1 mediates otic placode formation and jaw development. Development (Cambridge, England). 130(5):929-940

Kawahara, A. and Dawid, I.B. (2002) Developmental expression of zebrafish emx1 during early embryogenesis. Gene expression patterns : GEP. 2(3-4):201-206

Watanabe, M., Rebbert, M.L., Andreazzoli, M., Takahashi, N., Toyama, R., Zimmerman, S., Whitman, M., and Dawid, I.B. (2002) Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Developmental Dynamics : an official publication of the American Association of Anatomists. 225(4):448-456

Gothilf, Y., Toyama, R., Coon, S.L., Du, S.-J., Dawid, I.B., and Klein, D.C. (2002) Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 225(3):241-249

Kudoh, T., Wilson, S.W., and Dawid, I.B. (2002) Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Development (Cambridge, England). 129(18):4335-4346

Kawahara, A., Chien, C.-B., and Dawid, I.B. (2002) The homeobox gene mbx is involved in eye and tectum development. Developmental Biology. 248(1):107-117

Miyamoto, T., Kawahara, A., Teufel, A., Mukhopadhyay, M., Zhao, Y., Dawid, I.B., and Westphal, H. (2002) Mbx, a novel mouse homeobox gene. Development genes and evolution. 212(2):104-106

Hong, S.K., Kim, C.-H., Yoo, K.-W., Kim, H.S., Kudoh, T., Dawid, I.B., and Huh, T.L. (2002) Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish. Mechanisms of Development. 112(1-2):199-202

Tsang, M., Friesel, R., Kudoh, T., and Dawid, I.B. (2002) Identification of Sef, a novel modulator of FGF signalling. Nature cell biology. 4(2):165-169

Hibi, M., Hirano, T., and Dawid, I.B. (2002) Organizer formation and function. Results and problems in cell differentiation. 40:48-71

Hukriede, N., Fisher, D., Epstein, J., Joly, L., Tellis, P., Zhou, Y., Barbazuk, B., Cox, K., Fenton-Noriega, L., Hersey, C., Miles, J., Sheng, X., Song, A., Waterman, R., Johnson, S.L., Dawid, I.B., Chevrette, M., Zon, L.I., McPherson, J., and Ekker, M. (2001) The LN54 radiation hybrid map of zebrafish expressed sequences. Genome research. 11(12):2127-2132

Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. Genome research. 11(12):1979-1987

Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. ZFIN Direct Data Submission.

Kudoh, T. and Dawid, I.B. (2001) Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Mechanisms of Development. 109(1):95-98

Kawahara, A. and Dawid, I.B. (2001) Critical role of biklf in erythroid cell differentiation in zebrafish. Current biology : CB. 11(17):1353-1357

Kudoh, T. and Dawid, I.B. (2001) Role of the iroquois3 homeobox gene in organizer formation. Proceedings of the National Academy of Sciences of the United States of America. 98(14):7852-7857

Andreazzoli, M., Broccoli, V., and Dawid, I.B. (2001) Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA. Mechanisms of Development. 104(1-2):117-120

Dawid, I.B. and Chitnis, A.B. (2001) Lim homeobox genes and the CNS: a close relationship. Neuron. 30(2):301-303

Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation. Proceedings of the National Academy of Sciences of the United States of America. 97(22):12121-12126

Kawahara, A. and Dawid, I.B. (2000) Expression of the Kruppel-like zinc finger gene biklf during zebrafish development. Mechanisms of Development. 97(1-2):173-176

Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Functional interaction of vega2 and goosecoid homeobox genes in zebrafish. Genesis (New York, N.Y. : 2000). 28(2):58-67

Tsang, M., Kim, R., De Caestecker, M.P., Kudoh, T., Roberts, A.B., and Dawid, I.B. (2000) Zebrafish nma is involved in TGFb family signaling. Genesis (New York, N.Y. : 2000). 28(2):47-57

Kodjabachian, L., Dawid, I.B., and Toyama, R. (1999) Gastrulation in zebrafish: what mutants teach us. Developmental Biology. 213(2):231-245

Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proceedings of the National Academy of Sciences of the United States of America. 96(17):9745-9750

Hsieh, J.C., Kodjabachian, L., Rebbert, M.L., Rattner, A., Smallwood, P.M., Samos, C.H., Nusse, R., Dawid, I.B., and Nathans, J. (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 398(6726):431-436

Chitnis, A.B. and Dawid, I.B. (1999) Neurogenesis in zebrafish embryos. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:367-386

Rebagliati, M.R., Toyama, R., Haffter, P., Dawid, I.B. (1998) cyclops encodes a nodal-related factor involved in midline signaling. Proceedings of the National Academy of Sciences of the United States of America. 95:9932-9937

Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982

Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. (1998) Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Developmental Biology. 199:261-272

Dawid, I.B., Breen, J.J., and Toyama, R. (1998) LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends in genetics : TIG. 14(4):156-162

Toyama, R., Kobayashi, M., Tomita, T., and Dawid, I.B. (1998) Expression of LIM-domain binding protein (ldb) genes during zebrafish embryogenesis. Mechanisms of Development. 71:197-200

Glasgow, E., Karavanov, A.A., and Dawid, I.B. (1997) Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Developmental Biology. 192:405-419

Toyama, R. and Dawid, I.B. (1997) lim6, a novel LIM homeobox gene in the zebrafish: Comparison of its expression pattern with lim1. Developmental Dynamics : an official publication of the American Association of Anatomists. 209(4):406-417

Sheng, H.Z., Bertuzzi, S., Chiang, C., Shawlot, W., Taira, M., Dawid, I., and Westphal, H. (1997) Expression of murine Lhx5 suggests a role in specifying the forebrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 208(2):266-277

Minucci, S., Leid, M., Toyama, R., Saint-Jeannet, J.P., Peterson, V.J., Horn, V., Ishmael, J.E., Bhattacharyya, N., Dey, A., Dawid, I.B., and Ozato, K. (1997) Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Molecular and cellular biology. 17(2):644-655

Minucci, S., Saint-Jeannet, J.P., Toyama, R., Scita, G., DeLuca, L.M., Taira, M., Levin, A.A., Ozato, K., and Dawid, I.B. (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proceedings of the National Academy of Sciences of the United States of America. 93:1803-1807

Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I.B., and Eisen, J.S. (1995) Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development (Cambridge, England). 121:4117-4125

Toyama, R., Curtiss, P.E., Otani, H., Kimura, M., Dawid, I.B., and Taira, M. (1995) The LIM class homeobox gene lim5: implied role in CNS patterning in Xenopus and zebrafish. Developmental Biology. 170:583-593

Toyama, R., O'Connell, M.L., Wright, C.V.E., Kuehn, M.R., and Dawid, I.B. (1995) Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development (Cambridge, England). 121:383-391

Mahon, K.A. and Dawid, I.B. (1992) Development shows some backbone. HFSP Workshop on Genetic Control of Vertebrate Development cosponsored by the Human Frontier Science Program, European Science Foundation, and European Molecular Biology Organization, Les Diablerets, Switzerland, May 26-30, 1991. New. Biol.. 4(1):36-41

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