FIGURE

Fig. 8

ID

ZDB-FIG-250611-16

Publication

Qin et al., 2025 - Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

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Fig. 8

In vivo inhibition of intestinal inflammation by sCtla-4-Ig. (A) Percent initial weight of zebrafish after injection of the sCtla-4-Ig or the IgG isotype control. Each group consisted of six zebrafish (n=6). Data show means with SEM analyzed by two-way ANOVA with Sidak’s correction for multiple comparisons. (B) Representative H&E staining analysis of histopathological changes and quantitation of histology scores in the posterior intestine from ctla-4-/- zebrafish treated with sCtla-4-Ig or IgG isotype control. Scale bar: 50 μm. (C) The mRNA expression levels of inflammation-related genes in ctla-4-/- zebrafish treated with sCtla-4-Ig or IgG isotype control. (D) The mRNA expression levels of IBD biomarker genes and IBD-related genes in ctla-4-/- zebrafish treated with sCtla-4-Ig or IgG isotype control. The p-value was generated by an unpaired two-tailed Student’s t-test. **p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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