FIGURE

Figure 12

ID

ZDB-FIG-250428-115

Publication

Ye et al., 2025 - Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress

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Figure 12

The proposed mechanism underlying the anti-PD effect of epicoccin A. Epicoccin A co-treatments can reverse the abnormal expressions of genes related to neuronal development, contributing to the improvement of neuronal damage in PD. Co-treatments with epicoccin A improved the aberrant gene expressions in the mTOR/FoxO signaling pathway, which might activate pink1/parkin-dependent mitophagy. This process facilitated the degradation of damaged mitochondria and α-synuclein fibrils, thereby inhibiting the formation of LBs. Moreover, epicoccin A co-treatments can inhibit oxidative stress by reducing ROS accumulation, further enhancing mitophagy and consequently alleviating the onset and development of PD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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