FIGURE

Fig. 5

ID

ZDB-FIG-250403-76

Publication

Anderson et al., 2025 - Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function

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Fig. 5

β-cell–specific Dhps and Eif5a1 deletions in adult mice on β-cell mass expansion in response to 4 weeks of HFD. N = 4 mice per group. A, representative images (left panels) immunostained for insulin and quantitation of β-cell mass (right bar graphs) in littermate control, Dhps-Δβ, and Eif5a-Δβ mouse pancreata after 4 weeks of HFD. Scale bar represents 100 μm. Each point represents one mouse. B, volcano plot showing genes with altered expression in Dhps-Δβ mouse islets compared with Dhps control mouse islets; blue circles indicate genes that satisfy the cutoff threshold of p-adj <0.05 and fold change >2. C, Gene Ontology (GO) pathways of Dhps-Δβ mouse islets compared with littermate control mouse islets. D, gene set enrichment analysis of Dhps-Δβ mouse islets compared with littermate control mouse islets. Data are presented as mean ± SEM, and statistical significance was determined by an unpaired t test. HFD, high-fat diet.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.