STAT3-VDR molecular interplay. A Analysis of sequences of proximal promoter of vdra, vdrb, cyp24a1, cyp27b1 (A) and stat3 (A'); representative schemes of SBE (A) and VRE (A') consensus sequences. B Expression levels of stat3, socs3a, cebpb and vegfa in wild type 5-dpf zebrafish larvae treated for 2 days with vehicle or 0.5 nM vitamin D. C Expression level of Stat3 and Socs3 in L929 cells treated either with vehicle or 200 nM vitamin D for 24 hours. D Protein level quantification of pSTAT3(S727), pSTAT3(Y705) and pERK1/2, (respectively normalized on STAT3, STAT3 and ERK1/2,) of L929 cells treated either with vehicle or 200 nM vitamin D for 24 hours. Mean ± SEM. *p < 0.05, ****p < 0.0001.
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