FIGURE

Fig. 3

ID

ZDB-FIG-240315-14

Publication

Abbott et al., 2023 - A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

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Fig. 3

Comparison of ERα/ERβ PRL-HeLa biosensor models shows model sensitivity in differentiating ER selective compounds (A) Heatmap showing logEC50 values for GFP-ERβ:PRL-HeLa and GFP-ERα:PRL-HeLa cells treated with the indicated chemicals (10pM to 1 μM) for 2-h as measured by transcriptional reporter and chromatin remodeling features; (B) Transcriptional response (dsRED2) of ERα (red) and ERβ (green) PRL-array cells treated with multiple doses of a ERβ selective agonist (DPN), a ERβ selective antagonist (PHTTP), a ERα selective agonist (PPT), or a ERα selective antagonist (MPP). Results are shown as mean and standard deviation from 8 technical replicates. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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