FIGURE

Fig. 1

ID

ZDB-FIG-240212-26

Publication

Kim et al., 2024 - Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536

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Fig. 1

Generation of znf536 KO zebrafish and growth phenotype analysis.

A Generation of the znf536 KO line. Red asterisk (upper panel) and yellow box (lower panel) indicate the sgRNA target region. B Schematic representation of predicted proteins in the WT and KO. Blue boxes indicate the zinc finger C2H2 domains. C Genotype ratio for larval stage zebrafish from heterozygous incrosses (6–20 dpf) (n = 1433). D Representative images of znf536 WT and KO zebrafish at 3 and 6 mpf adult stages. n = 14 for WT, n = 44 for Het, and n = 9 for KO (3 mpf); n = 9 for KO (6 mpf). Scale bar: 10 mm.

Expression Data

Expression Detail

No data available

Antibody Labeling

Phenotype Data

Fish:	znf536^{ck109a/ck109a} znf536^ck109a/+
Condition:	housing conditions
Observed In:	whole organism
Stage Range:	Days 14-20 to Adult

Phenotype Detail

Fish	Conditions	Stage	Phenotype
znf536^ck109a/+	standard conditions	Days 14-20	whole organism viability, normal
znf536^{ck109a/ck109a}	standard conditions	Days 14-20	whole organism viability, abnormal
znf536^{ck109a/ck109a}	standard conditions	Adult	whole organism decreased size, abnormal
znf536^{ck109a/ck109a}	housing conditions	Adult	whole organism normal size, normal

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Acknowledgments

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