FIGURE

Fig. 7

ID

ZDB-FIG-240124-36

Publication

Rodríguez-Ruiz et al., 2023 - ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome

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Fig. 7

ZAKα regulates hematopoiesis in zebrafish through the Nlrp1 inflammasome A–K Number of neutrophils (B, D, H), erythrocytes (F) and macrophages (J), and caspase‐1 activity (K) in 2 dpf larvae either treated from 1 to 2 dpf by bath immersion with 1 μM nilotinib and/or 100 μM anisomycin (A–D) or obtained by injecting one‐cell stage embryos with standard or zaka crRNAs/Cas9 complexes (E–K). Representative images of neutrophils (A, C, G), erythrocytes (E) and macrophages (I) are also shown. Each dot represents one individual and the mean ± SEM for each group is also shown. P values were calculated using one‐way ANOVA and Tukey's multiple range test (B) or Student's t‐test (D, F, H, J, K). Data are shown as the means ± SEM of two technical replicates in (K). n.s., non‐significant; *P < 0.05; **P < 0.01; ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.