Fig. 10.

Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts. Diagram summarizing the results of this study. Three stages of tooth replacement are shown for each fish species; the site of each event is indicated by the dashed ovals in the diagrams. In both fish species, the initiation stage is hypothesized to occur at the successional dental epithelium (which in zebrafish is arranged as a successional dental lamina). Thereafter, tooth germs differentiate and grow in size as they deposit dentine and enameloid. Later, tooth dissociation occurs, thus making space for the new tooth. Arrows and hammers indicate that a given gene overexpression treatment yielded a significant increase or decrease in the indicated event, respectively. Note that these could be indirect effects; for example, stickleback Wnt10a may increase tooth dissociation indirectly by increasing tooth initiation.