FIGURE

Fig. 3

ID

ZDB-FIG-231208-29

Publication

Celeghin et al., 2023 - A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Impaired motor behaviour and exercise-induced mortality in zebrafish Dsp mutant larvae.

A–A′–A″: Birefringence analysis on WT and mutant larvae at 5 dpf does not detect any significant difference in the skeletal muscles structure. All embryos are at 5 dpf, in lateral view, anterior to the left. Sample size: WT n = 20; -ab n = 30. R.I. relative intensity. Error bars: SEM. ns not significant. Test: Unpaired t-test. B–B′: WT and -ab larvae at 5 dpf display normal response to light (white areas) and dark (grey areas) stimuli, but with reduced motor performances if mutated, evaluated as total distance swum (B). Sample size: n = 36. Error bars: SEM. *p < 0.05. Test: Unpaired t-test. C A mild training protocol was applied on larvae from 3 to 13 dpf, for 10 days. A statistically significant increase in mortality was observed in trained mutants when compared with resting controls (p < 0.0001). Sample size: n = 50. Error bars: SEM. Test: Log-rank (Mantel–Cox) test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Discov