FIGURE

Fig. 1

ID

ZDB-FIG-231204-27

Publication

Schoenmakers et al., 2023 - Selenoprotein deficiency disorder predisposes to aortic aneurysm formation

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Fig. 1

Thoracic aortic aneurysms with cystic medial necrosis.

A CT imaging of P1 showing aortic valve and ascending aorta replacement at age 23 years (orange arrow) and distal arch dilatation (white arrow) at age 44 years. MR imaging of P2 and P3 showing dilatation of the aortic root (red star), with effacement of the sinotubular junction (red arrows). Echocardiogram of P4 showing positions (1, annulus; 2, root; 3, sinotubular junction; 4, tract) of abnormal aortic dimensions (upper panel) and aortic valvular insufficiency (lower panel). B Histochemistry and TUNEL/immunohistochemistry of control thoracic aorta (C), P1a (ascending aorta), P1b (aortic arch) or P2 (ascending aorta), using Movat’s pentachrome, Elastin van Gieson (EVG), Alcian Blue, and von Kossa stains, and terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) with anti-α-smooth muscle actin (SMA/Acta2). Outlined areas in Movat’s sections are shown in higher power in subsequent stains. Insets in TUNEL/SMA sections are high-power views of TUNEL-positive cells (arrows). Scale bars: 1 mm in Movat’s, 250 μm in other panels. C Immunohistochemistry of control ascending aorta (C), or P1b and P2 thoracic aorta for 8-oxoguanine (8-Oxo-G, left panels) or γ-H2AX (right panels), co-stained with anti-SMA. Insets are high-power views of outlined areas. Scale bars: 250 μm. B and Cn = 1 independent experiment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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