FIGURE

Fig. 3.

ID

ZDB-FIG-231118-20

Publication

Li et al., 2023 - The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling

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Fig. 3.

Wnt signaling is downregulated upon csde1 deficiency. (A) Volcano plots showing the differentially expressed genes in ECs between WT siblings and csde1 mutants. (B) Gene ontology analysis for the downregulated genes in csde1 mutants, compared with WT siblings. (C) GSEA analysis of genes associated with canonical Wnt signaling pathway in csde1 mutants compared with WT siblings. (D) qPCR analysis of Wnt signaling genes cyclin D1, cdk2, axin2, lef1 and tcf3 in ECs in control and csde1 morphants at 36 hpf. Data are mean±s.d. **P<0.01, ***P<0.001 (two-tailed unpaired Student's t-test). n=3 replicates.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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