Gene
tcf3a
- ID
- ZDB-GENE-990415-51
- Name
- transcription factor 3a
- Symbol
- tcf3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within striated muscle cell development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Is expressed in heart. Human ortholog(s) of this gene implicated in agammaglobulinemia 8A; agammaglobulinemia 8B; and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140653 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chong et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR3-tcf3a | Gu et al., 2020 | |
| CRISPR4- tcf3a | Gu et al., 2020 | |
| MO1-tcf3a | N/A | Chong et al., 2007 |
| MO2-tcf3a | N/A | Chong et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agammaglobulinemia 8A | Alliance | Agammaglobulinemia 8A, autosomal dominant | 616941 |
| agammaglobulinemia 8B | Alliance | Agammaglobulinemia 8B, autosomal recessive | 619824 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neuronal Differentiation E-box Binding Transcription Factors |
|---|---|---|---|---|---|
| UniProtKB:Q90491 | InterPro | 583 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(LOXP-tcf3a-FRT,myl7:DsRedx-FRT-LOXP) |
| 1 | Gu et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-201N22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140653 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113926 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131094 (1) | 2232 nt | ||
| Genomic | GenBank:CR391909 (2) | 158411 nt | ||
| Polypeptide | UniProtKB:Q90491 (1) | 583 aa |
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
- Davis, E.E., Balasubramanian, R., Kupchinsky, Z.A., Keefe, D.L., Plummer, L., Khan, K., Meczekalski, B., Heath, K.E., Lopez-Gonzalez, V., Ballesta-Martinez, M.J., Margabanthu, G., Price, S., Greening, J., Brauner, R., Valenzuela, I., Cusco, I., Fernandez-Alvarez, P., Wierman, M.E., Li, T., Lage, K., Barroso, P.S., Chan, Y.M., Crowley, W.F., Katsanis, N. (2020) TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Human molecular genetics. 29(14):2435-2450
- Gu, S., Li, J., Li, S., Cao, J., Bu, J., Ren, Y., Du, W., Chen, Z., Xu, C., Wang, M., Jiang, L., Huang, C., Du, J. (2020) Efficient replacement of long DNA fragments via non-homologous end joining at non-coding regions. Journal of molecular cell biology. 13(1):75-77
- Huang, Y., Huang, C.X., Wang, W.F., Liu, H., Wang, H.L. (2020) Zebrafish miR-462-731 is required for digestive organ development. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 34:100679
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Wu, Y., Li, W., Yuan, M., Liu, X. (2019) The synthetic pyrethroid deltamethrin impairs zebrafish (Danio rerio) swim bladder development. The Science of the total environment. 701:134870
- Cai, C., Sang, C., Du, J., Jia, H., Tu, J., Wan, Q., Bao, B., Xie, S., Huang, Y., Li, A., Li, J., Yang, K., Wang, S., Lu, Q. (2018) Knockout of tnni1b in zebrafish causes defects in atrioventricular valve development via the inhibition of the myocardial wnt signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(1):696-710
- Chi, Y., Huang, Z., Chen, Q., Xiong, X., Chen, K., Xu, J., Zhang, Y., Zhang, W. (2018) Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.. Open Biology. 8(7):
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
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