FIGURE

Fig. 6

ID

ZDB-FIG-231009-22

Publication

Ng et al., 2023 - The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

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Fig. 6

Model of USP46 complex regulation of LRP6 in the Wnt pathway.

A The USP46 complex catalyzes the deubiquitylation of LPR6, opposing the activities of RNF34 and ZNFR3 (and potentially other E3 ligases) to maintain low homeostatic levels of LRP6. B Upon Wnt ligand binding to Frizzled and LPR6, the USP46 complex is recruited to and deubiquitylates LPR6, allowing LRP6 to be assembled into the Wnt signalosome.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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