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Fig. 6

ID: ZDB-IMAGE-231009-22
Source: Figures for Ng et al., 2023

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Figure Caption

Fig. 6 Model of USP46 complex regulation of LRP6 in the Wnt pathway.

A The USP46 complex catalyzes the deubiquitylation of LPR6, opposing the activities of RNF34 and ZNFR3 (and potentially other E3 ligases) to maintain low homeostatic levels of LRP6. B Upon Wnt ligand binding to Frizzled and LPR6, the USP46 complex is recruited to and deubiquitylates LPR6, allowing LRP6 to be assembled into the Wnt signalosome.

Acknowledgments

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