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ZDB-FIG-231004-57

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Uribe et al., 2023 - Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro

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Fig. 1

MM-201 protects mouse utricular hair cells from neomycin exposure in vitro. (A-C) Representative images of utricular extrastriolar hair cell densities from explants treated with (A) control culture medium, (B) 2 mM neomycin, or (C) 2 mM neomycin plus 1 pM MM-201. Scale bar applies to all three images. (D) 1 pM of MM-201 robustly protects utricular hair cells from neomycin exposure whereas 1 µM does not exhibit significant protection (One-way ANOVA: F_3,38=10.68 p<0.0001). Asterisks indicate significant difference from 2 mM neomycin treated group (****p<0.001). N = 4–6 utricular explants per treatment, error bars represent + s.d.

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Reprinted from Hearing Research, 434, Uribe, P.M., Hudson, A.M., Lockard, G., Jiang, M., Harding, J., Steyger, P.S., Coffin, A.B., Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro, 108786108786, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.