Fig. 7
- ID
- ZDB-FIG-230726-9
- Publication
- Geng et al., 2023 - Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality
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Dopamine D3 agonists rescue social deficits in VPA-treated fish (A) Comparing the behavioral fingerprints of D1, D2, and D3 agonists. The behavioral fingerprints are normalized and subtracted by the median DMSO fingerprint. (B) PDF maps of DMSO-treated fish (n = 356) and fish treated by D3 agonists (n = 49). (C) Series of images taken at 0.5 s intervals reveal different swim dynamics between wild type treated by DMSO and fish treated by the D3 agonist piribedil (10 μM). Arrows in red and yellow point to fish’s direction of movement in the current frame. (D) Boxplot showing social preference (social score) of DMSO-treated fish (n = 12) or VPA-treated fish acutely exposed to DMSO (n = 16) or 10 μM D3 agonist including pramipexole (n = 17), piribedil (n = 20), and 7-hydroxy-DPAT-HBr (n = 24) for 1 h before social preference test. In each boxplot, box encloses datapoints from the 25th percentile to the 75th percentile, the horizontal line and cross mark the median and the mean, and the lines above and below the box reach datapoints with the maximum and minimum values. ∗p < 0.05, ∗∗∗p < 0.001. (E) PDF maps of DMSO-treated fish (n = 10) and VPA-treated fish acutely exposed to DMSO (n = 10) or 10 μM D3 agonist including pramipexole (n = 10), piribedil (n = 10), or 7-hydroxy-DPAT-HBr (n = 10) for 1 h before ZeChat test. |