Figure 7
- ID
- ZDB-FIG-230427-44
- Publication
- Hußmann et al., 2023 - Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner
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(A–G) Confocal images of blood and lymphatic vasculature in the trunk of 2-dpf-old embryos derived from svep1; tie1 double heterozygous fish, showing severely reduced PL numbers in svep1; tie1 double mutants and significant decrease of PL cell numbers in svep1+/−; tie1−/− compared to svep1+/+; tie1−/− (**p = 0.0012). (H) Quantification of PL cell numbers at 2 dpf using Mann–Whitney test (siblings: n = 45; svep1+/−; tie1+/−: n = 45; svep1−/−; tie1+/+: n = 13; svep1+/+; tie1−/−: n = 15; svep1−/−; tie1+/−: n = 20; svep1+/−; tie1−/−: n = 21; svep1−/−; tie1−/−: n = 11). Scale bar = 100 µm. Values are presented as means ± standard deviation (SD), ****p < 0.0001, ***p = 0.007, *p = 0.0163, ns = not significant. dpf, days post-fertilization; PL, parachordal lymphangioblast.
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