FIGURE

Fig. 6

ID

ZDB-FIG-230405-13

Publication

Tan et al., 2022 - Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear

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Fig. 6

Effects of signal modulation on reporters of Fgf and Wnt signaling. (A) Dorsolateral views showing expression of Wnt reporter top:gfp (a–e) or Fgf-target etv5b (f–j) at 24 hpf under conditions indicated at the top. (B) Cross-sections (dorsal to the top, medial to the left) of etv5b-stained embryos passing through the anterior or middle the otic vesicle, as indicated on the left. Black arrows (e, f) indicate regions of weaker expression of etv5b. (C) Dorsolateral views showing expression of fgf3, fgf8a and fgf10a at 24 hpf in control and BIO-treated embryos. Pharyngeal endoderm (pe) is marked (Ca, Cb). (D) Cross-sections of embryos showing expression of sp5a and top:gfp at 24 hpf following treatments from 12 hpf, as indicated at the top. Scale bars (Aa, Ba, Ca, Da), 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 492, Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B., Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear, 139-153, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.