FIGURE

Fig. 2

ID

ZDB-FIG-221101-34

Publication

Angom et al., 2021 - LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

LCC-09 inhibits LPS-induced inflammatory response in zebrafish. (A–D) Zebrafish (MPO;GFP) embryos at 48 hpf were treated with LCC-09 (5 μM) and DMSO as control for 3 h and then injected with LPS (0.4 mg/mL, 2 nL) through yolk sac. Images were collected 12 h after injection (B). Local accumulation of neutrophils was quantified using GFP fluorescent intensity and compared (C). Zebrafish survival was monitored (N=8 per group) (D). (E–G) LPS (0.4 mg/mL, 2 nL) was intravenously injected to the caudal vein of zebrafish (MPO;GFP) embryos at 48 hpf. Images were collected 6 h post-injection. Neutrophil accumulation in tail fins (outlined by yellow dotted dash lines) was counted and compared. Arrow denotes infiltration of GFP positive neutrophils induced by LPS injection. *p<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Inflamm Res