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FIGURE 2

ID

ZDB-FIG-221029-40

Publication

Yamashita et al., 2022 - Receptor subunit compositions underly distinct potencies of a muscle relaxant in fast and slow muscle fibers

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FIGURE 2

The effect of pancuronium on end-plate currents in fast and slow muscle fibers. (A) Fluorescent image of 4 dpf Tg (hb9:tTAad, TRE:ChRFR-TagRFP) zebrafish. Motor neurons specifically expressed channelrhodopsin fused with TagRFP. (B) Representative current traces from fast (top) and slow (bottom) muscle fibers in response to the light stimulation in the presence of pancuronium, whose concentration in the solution is indicated above the traces. Note some of the traces have notches, which result from the non-overlapping time course of inputs from multiple motor neurons innervating the muscle cell. (*p < 0.05, Student’s t-test with bonferroni correction) (C) The effect of pancuronium on EPC charges. Light-evoked EPCs were recorded in the varying concentration of pancuronium.

Expression Data

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Antibody Labeling

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Physiol.