FIGURE

Fig. 6

ID

ZDB-FIG-221028-21

Publication

Cacialli et al., 2022 - Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates

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Fig. 6

Slco2b1‐overexpression in ECs can rescue the loss of HSPCs in slco2b1‐ morphants

A,B
(A) WISH for cmyb at 60hpf in kdrl:Gal4+ embryos injected with control‐ and slco2b1‐ morpholinos and/or co‐injected with the Tol2‐UAS:slco2b1 vector and tol2 mRNA. The region indicated by the dashed has been magnified and shown in (B).
C
Quantification and statistical analysis were completed using one‐way ANOVA and multiple comparison tests. ****P < 0.0001. Center values denote the mean, and error bars denote s.e.m. Each dot represents the number of cmyb‐expressing cells for each embryo (biological replicates). Each experiment has been repeated three independent times.

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Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bw9Tg/bw9Tg + MO2-slco2b1
Knockdown Reagent:	MO2-slco2b1
Observed In:	caudal hematopoietic tissue prostaglandin biosynthetic process caudal hematopoietic tissue regulation of prostaglandin-E synthase activity endothelial cell regulation of prostaglandin-E synthase activity
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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