FIGURE

Fig. 2

ID

ZDB-FIG-220819-59

Publication

Wang et al., 2022 - The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells

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Fig. 2

FBN1 knockout decreases glycolysis and angiogenesis. (A) FBN1‐knockout cisplatin‐resistant ovarian cancer organoids and cell lines were verified by Western blotting. (B) GSEA analysis was performed using FBN1‐knockout and control cisplatin‐resistant ovarian cancer organoids (CR‐organoid/FBN1‐KO1 and NC). The signature was defined by genes showing significant expression changes. (C) Gene ontology of mass spectrum analysis in CR‐organoid/FBN1‐KO1 and CR‐organoid/NC. (D) Pathway examination of mass spectrum analysis in CR‐organoid/FBN1‐KO1 and CR‐organoid/NC. (E) Metabolites in pathways of glucose metabolism. (F) mRNA levels of genes altered by FBN1 knockout in cisplatin‐resistant ovarian cancer organoids and cell lines. Abbreviations: FBN1, fibrillin‐1; GSEA, Gene Set Enrichment Analysis; CR, cisplatin‐resistant; KO, knockout; NC, negative control

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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