ZFIN Image: Wang et al., 2022, Fig. 2

Image

Figure Caption

Fig. 2

FBN1 knockout decreases glycolysis and angiogenesis. (A) FBN1‐knockout cisplatin‐resistant ovarian cancer organoids and cell lines were verified by Western blotting. (B) GSEA analysis was performed using FBN1‐knockout and control cisplatin‐resistant ovarian cancer organoids (CR‐organoid/FBN1‐KO1 and NC). The signature was defined by genes showing significant expression changes. (C) Gene ontology of mass spectrum analysis in CR‐organoid/FBN1‐KO1 and CR‐organoid/NC. (D) Pathway examination of mass spectrum analysis in CR‐organoid/FBN1‐KO1 and CR‐organoid/NC. (E) Metabolites in pathways of glucose metabolism. (F) mRNA levels of genes altered by FBN1 knockout in cisplatin‐resistant ovarian cancer organoids and cell lines. Abbreviations: FBN1, fibrillin‐1; GSEA, Gene Set Enrichment Analysis; CR, cisplatin‐resistant; KO, knockout; NC, negative control

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cancer Commun (Lond)