FIGURE

Figure 4

ID

ZDB-FIG-220801-56

Publication

Lin et al., 2022 - Quantification of Idua Enzymatic Activity Combined with Observation of Phenotypic Change in Zebrafish Embryos Provide a Preliminary Assessment of Mutated idua Correlated with Mucopolysaccharidosis Type I

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Figure 4

Knockdown of z-idua caused defective head cartilage in zebrafish embryos. Using alcian blue staining to detect the head cartilage of zebrafish embryos at 120 hpf. Untreated embryos (control) and embryos injected with antisense morpholino oligonucleotides (MO) complementary with z-idua (z-idua-MO) were studied. (A,B) Lateral view; (C,D) Ventral view; (A,C) Untreated control embryos; and (B,D) z-idua-MO injected embryos. Loss of function of z-Idua caused deformed cranial cartilage and decreased number of cartilage cells. cb, ceratobranchial; ch, ceratohyal; ep, ethmoid plate; m, Meckel’s cartilage; pq, palatoquadrate; tr, trabecular plate. Scale bar: 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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