FIGURE

Figure 3

ID

ZDB-FIG-220801-55

Publication

Lin et al., 2022 - Quantification of Idua Enzymatic Activity Combined with Observation of Phenotypic Change in Zebrafish Embryos Provide a Preliminary Assessment of Mutated idua Correlated with Mucopolysaccharidosis Type I

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Figure 3

Knockdown of z-idua caused defective development in zebrafish embryos. Embryonic phenotypes were observed in 120 hpf zebrafish embryos injected with 12 ng z-idua-MO. (A) Untreated control embryos; (B,C): z-idua-MO-injected embryos; (B) defective head, including smaller eyes, abnormal craniofacial and pharyngeal arches, and cardiac edema; (C) defective body shape, including shortened somites and bent body axis. (D) Percentage of defective phenotypes occurring in all examined embryos injected with z-idua-MO. Embryonic morphology was examined at 120 hpf in the zebrafish embryos injected at one-cell stage with different concentrations of z-idua-MO, as indicated. The occurrence rates (in percentages) of defective phenotypes (marked in black boxes) and the wild type-like phenotype (marked in grey) among the total examined embryos injected were calculated. The total number (n) of embryos studied in each group was indicated at the top of each column. Scale bar: 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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