FIGURE

Figure 5

ID

ZDB-FIG-220801-139

Publication

Hawkey-Noble et al., 2022 - Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis

Other Figures

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Figure 5

Calcein staining illustrating the impact of foxl1 loss on axial skeletal development and calcification. (A) WT and foxl1^-/- embryos at 6 and 10 dpf showing normal formation of the vertebrae in foxl1. (B,C) Experimental groups of calcein staining illustrating the variability in calcification of the zebrafish vertebrate between WT and foxl1 homozygotes at 6 and 10 dpf, respectively (* p < 0.05, ** p < 0.01, *** p < 0.001), showing an increased trend in number of calcified vertebrae in foxl1 mutants by 10 dpf. Total number of calcified vertebrae were counted by including both complete and partially calcified vertebrae [partially calcified vertebrae are indicated by disconnected primary and secondary centres of ossification (red arrows)]. Scale bars are 500 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxl1^nfl1/nfl1 (AB)
Observed In:	vertebra ossification
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genes (Basel)