FIGURE

Fig. 5

ID

ZDB-FIG-220628-115

Publication

Radhakrishnan et al., 2022 - Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function

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Fig. 5

Rbpr2^−/− mice on vitamin A-deficient diets show decreased ocular retinoid concentrations and shorter photoreceptor outer segments. (A) Ultrastructural analysis of photoreceptors using transmission electron microscopy (TEM): Representative TEM images of photoreceptors from 12-week old WT and Rbpr2^−/− mice on vitamin A-deficient diets are presented. Scale bar = 600 μm. RPE, retinal pigmented epithelium; OS, outer segments. Data are representative of n = 6 retinal sections per eye from n = 4 mice per genotype. (B) Quantification of total retinoid concentrations (pmole/eye) in eyes from WT, Rbpr2^+/−, and Rbpr2^−/− mice (eyes from n = 8 mice per genotype). ** p < 0.005, Rbpr2^−/− compared to controls.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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