FIGURE

FIGURE 3

ID

ZDB-FIG-220406-14

Publication

Zhou et al., 2022 - Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

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FIGURE 3

Alteration of dopamine and its metabolites levels in zebrafish larvaes and SH-SY5Y cells after aconitine exposure. (A) Dopamine, DOPAC and HVA levels and the turnover of dopamine after larvaes were treated with 1 μM aconitine for 0.5, 3, 6, and 24 h, respectively. (B) Dopamine, DOPAC and HVA contents and the turnover of dopamine after larvaes were incubated with aconitine at doses of 0.5, 1 and 2 μM for 24 h. (C) Intracellular dopamine, DOPAC and HVA levels and the turnover of dopamine at doses of 50, 100, and 200 μM for 24 h in SH-SY5Y cells. (D) Extracellular dopamine, DOPAC and HVA levels and the turnover of dopamine at doses of 50, 100, and 200 μM for 24 h in SH-SY5Y cells. The values are expressed as mean ± SD, n = 3. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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