FIGURE

FIGURE 1

ID

ZDB-FIG-220406-11

Publication

Zhou et al., 2022 - Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

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FIGURE 1

Morphological and swimming behavior changes of zebrafish larvaes after aconitine exposure. (A) Mortality of zebrafish larvaes exposed to aconitine at different concentrations (0.937–30 μM), n = 30. (B–F) Effects of exposure to aconitine on morphological parameters of zebrafish larvaes. Images were taken under a stereomicroscope (32× or 100×), n = 15. (D) Body length (μm). (E) Ocular distance (μm). (F) The surface area of eyes (μm²). (G–N) Effects of exposure to aconitine on neurobehavioral of zebrafish larvaes, n = 10. (G) Behavior trajectories. (H) Distance travelled (mm). (I) Movement speed (mm/s). (J) Time mobile (s). (K) Angular velocity (degree/s). (L) Meander (degree/mm). (M) CW rotation. (N) Frequency of visits to edge zone (%). The values are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control groups.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol