FIGURE

Figure 1

ID

ZDB-FIG-220219-76

Publication

Reuter et al., 2022 - Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart

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Figure 1

Transcriptional analysis identifies global changes in the aging zebrafish heart. (A) Scheme illustrating our transcriptome profiling approach with ventricles of 7-months (young) and 4-year (old) old zebrafish. n = 3. (B) Volcano plot illustrating differential gene expression (DEG) analysis that identified 1233 differentially expressed genes (DEGs); p_adj < 0.05 (dotted line). DEGs down-regulated in old vs. young are highlighted in blue (488), DEGs up-regulated in red (745). Gene symbols of top 50 DEGs (most significantly changed) are shown. FC: fold change. (C) Comparison DEGs in old vs. young with DEGs in hearts of klotho mutant vs. wild type [32] identifies 520 overlapping genes (D) 92.7% of 520 overlapping genes (in dark grey) are regulated in the same direction in old vs. young and mutant vs. wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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