FIGURE

Figure 8

ID

ZDB-FIG-220203-56

Publication

Zhu et al., 2021 - Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication

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Figure 8

A trio by Bms1l, Rcl1, and Ttf1 resolves the head-on conflict between rDNA transcription and replication. (A) A model to propose Bms1l as a mediator in balancing ribosome biogenesis through interaction with Rcl1 and replication fork progression through interaction with Ttf1. (B) Compromising Bms1 function not only impairs ribosome biogenesis but also accumulates Ttf1 on RFB-sites to cause replication fork stall together with genomic DNA partial over-replication and cell cycle arrest at the S-phase.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Mol. Cell Biol.