FIGURE

Figure 3

ID

ZDB-FIG-220131-528

Publication

Hentig et al., 2021 - Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a

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Figure 3

CNQX attenuates PTS in Shh-inhibited fish. (A) Percentage of undamaged and sTBI that were Shh inhibited (cyclopamine-treated) and cotreated with either valproic acid (VPA), gabapentin (GABAP), or CNQX that displayed spontaneous seizure events across 5 dpi. (B) Quantification of survival across 5 days of undamaged or sTBI Shh-inhibited fish cotreated with VPA, GABAP, or CNQX. Statistical analysis of the repeated-measures data was performed with the Friedman test, n = 100 fish per control/experimental group, grey box denotes period of cyclopamine/(VPA or GABAP or CNQX) administration, ## p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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