FIGURE

Figure 7.

ID

ZDB-FIG-211207-89

Publication

Trofimenko et al., 2021 - Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Other Figures

All Figure Page

Back to All Figure Page

Figure 7.

Model of cell-penetrating peptide (CPP) direct translocation through water pores.

Cationic CPP translocation across cellular membranes is favored by the opening of potassium channels or by hyperpolarizing drugs, such as valinomycin. This sets a sufficiently low membrane potential permissive for CPP direct translocation. When cationic CPPs bind to these already polarized membranes, they induce megapolarization (i.e. a membrane potential estimated to be –150 mV or lower). This leads to the formation of water pores that are then used by CPPs to enter cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife