FIGURE

Figure 6

ID

ZDB-FIG-211201-205

Publication

Schmitner et al., 2021 - Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

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Figure 6

pax6-expressing progenitors are not increased in chronic hyperglycemia. Tg(pax6b:dsRed) labeled cells (magenta) in the INL (a,b) and the CMZ (e,f) in 3 mpf control and pdx1^−/− mutant retinas. Proliferating cells are labeled through EdU incorporation (green). In 6 mpf controls (c,g) and pdx1^−/− mutants (d,h), pax6b:dsRed expression was not observed in the central area of the retina and was limited to few cells in the CMZ. In situ hybridization for pax6a stained cells in the basal portion of INL in the central area of the retina (i–l) and in the CMZ (i′–l′) in controls (i,i′,k,k′) and pdx1^−/− mutants (j,j′,l,l′) at 3 mpf and 6 mpf. Scale bar: 50 µm. (GC, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer).

Expression Data

Gene:	pax6a
Antibody:	Ab1-DsRed
Fish:	ulg302Tg pdx1^sa280/sa280; ulg302Tg
Anatomical Terms:	ciliary marginal zone retina central region retinal inner nuclear layer
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdx1^sa280/sa280; ulg302Tg
Observed In:	ciliary marginal zone cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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