FIGURE

Figure 4

ID

ZDB-FIG-211201-203

Publication

Schmitner et al., 2021 - Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

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Figure 4

Chronic hyperglycemia impacts proliferation in progenitor populations. Cryosections of control and pdx1^−/− retinas at 3 mpf (a), 6 mpf (b) and 10 mpf (c). Cryosections were stained for EdU to identify cells that underwent proliferation (green) and counterstained with DAPI (blue). (d,e) Quantification of EdU positive cells in the ciliary marginal zone (CMZ) depicted in a box plot (d) and the same data shown as a line plot over time (e). Quantification of EdU positive cells in the ONL (f) and the INL (g) at 3, 6 and 10 mpf. Box plot extends from 75% to 25%, showing all data points, line indicates median. n = 4–10 fish per time point. Scale bar: 50 µm. (GC, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdx1^sa280/sa280
Observed In:	ciliary marginal zone cell population proliferation retinal inner nuclear layer cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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