FIGURE

Fig. 2

ID

ZDB-FIG-211109-2

Publication

Soll et al., 2021 - A Synthetic SOD/Catalase Mimic Compound for the Treatment of ALS

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Fig. 2

1-Fe treatment improved mSOD1 larvae motor performance. (A) The distance that mSOD1 larvae swam per time bin of 1 min following light stimuli was averaged for all larvae. mSOD1 larvae were treated with either vehicle (0.1% DMSO; Ct), 0.05, 0.1, 1 or 5 μM 1-Fe (* p < 0.05; linear mixed model, Tukey post hoc test, n = 94-6/group). (B) The change (%) in the distance the mSOD1-treated larvae swam compared to their vehicle-treated mSOD1 counterparts. The distances were averaged per fish for the whole period following light stimuli, scaled per plate and compared between treatments (* p < 0.05; *** p < 0.001; one-way ANOVA, Tukey post hoc test; n = 94-6/group). (C) Characteristic swimming paths of individual larvae for 60 s. Restoration of the swimming pattern was observed following treatment with 1-Fe.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os6Tg
Observed In:	locomotory behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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