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Fig. 2 1-Fe treatment improved mSOD1 larvae motor performance. (A) The distance that mSOD1 larvae swam per time bin of 1 min following light stimuli was averaged for all larvae. mSOD1 larvae were treated with either vehicle (0.1% DMSO; Ct), 0.05, 0.1, 1 or 5 μM 1-Fe (* p < 0.05; linear mixed model, Tukey post hoc test, n = 94-6/group). (B) The change (%) in the distance the mSOD1-treated larvae swam compared to their vehicle-treated mSOD1 counterparts. The distances were averaged per fish for the whole period following light stimuli, scaled per plate and compared between treatments (* p < 0.05; *** p < 0.001; one-way ANOVA, Tukey post hoc test; n = 94-6/group). (C) Characteristic swimming paths of individual larvae for 60 s. Restoration of the swimming pattern was observed following treatment with 1-Fe.