FIGURE

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ID

ZDB-FIG-211025-62

Publication

Gong et al., 2021 - Nitazoxanide induced myocardial injury in zebrafish embryos by activating oxidative stress response

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FIGURE 2

Toxic effect of NTZ exposure on embryonic heart of zebrafish. Live zebrafish embryos were exposed to vehicle control (0.1% DMSO) or NTZ at varying concentrations (0, 0.5, 1.0 and 2.0 mg/L) at 6 hpf and were observed at 72 hpf. (A–B) Enlarged high-resolution images of the embryonic heart area in zebrafish under white light. (A'–D’) Tg (myl7: GFP) diastolic heart imaged in zebrafish embryos in vivo. Quantification of cardiac shape and function (E) pericardial area (μm²), (F) heart rate (beats/20 seconds) and (G) SV-BA distance (μm²). Note: n = 50 larvae per group. Scale bar: 100 μm in panels a–d, a'–d’). The data were presented as the mean ±standard deviation. *p < 0.05; **p < 0.01 and ***p < 0.001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.