FIGURE

Fig. 8

ID

ZDB-FIG-210712-9

Publication

Butti et al., 2021 - Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

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Fig. 8

C9orf72 regulates synaptic active zones and activity at the neuromuscular junction.

a FM1-43 loading of NMJ boutons in 6 dpf fish. C9-miR fish displayed decreased FM1-43 loading compared to controls. b Quantification of FM1-43 fluorescent intensity in control (n = 14) and C9-miR fish (n = 16), showing a reduced FM1-43 fluorescent intensity in C9-miR fish (p < 0.0001; Student’s t test). c Putative synapses (arrows) were visualized with Rab3a immunostaining at 6 dpf (inset; scale bar = 10 μm). Rab3a+ synaptic puncta were reduced in number (d) and area (e) in 6 dpf C9-miR larvae when compared with wild-type controls (n = 5; ***p < 0.0001; Student’s t test). Scale bar = 50 μm. Data are presented as mean ± SEM. n represents the number of fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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