FIGURE

Figure 4.

ID

ZDB-FIG-210708-72

Publication

Pollock et al., 2021 - Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein

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Figure 4.

(A–C) There does not appear to be a difference in the maturation or localization of e-cadherin in either 5ng prp1 morpholino injected AB zebrafish or uninjected prp1^{ua5003/ua5003}; prp2^{ua5001/ua5001} homozygous mutant fish compared to uninjected wild-type controls. (F–E) After 3dpf wild-type larvae injected with prp1 MO (f) show significant signs of necrosis and developmental abnormalities compared to uninjected and control injected larvae (d, e)

Expression Data

Antibody:	Ab2-cdh1
Fish:	AB AB + MO1-prnpb prnpb^{ua5003/ua5003}; prnprs3^{ua5001/ua5001}
Knockdown Reagent:	MO1-prnpb
Anatomical Term:	DEL plasma membrane
Stage:	Shield

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-prnpb prnpb^{ua5003/ua5003}; prnprs3^{ua5001/ua5001}
Knockdown Reagent:	MO1-prnpb
Observed In:	intracellular protein localization whole organism
Stage Range:	Shield to Protruding-mouth

Phenotype Detail

Acknowledgments

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