ZFIN ID: ZDB-FIG-210708-72
Pollock et al., 2021 - Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein. Prion   15:70-81 Full text @ Prion
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibody:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Shield
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Shield to Protruding-mouth

Figure 4.

(A–C) There does not appear to be a difference in the maturation or localization of e-cadherin in either 5ng prp1 morpholino injected AB zebrafish or uninjected prp1ua5003/ua5003; prp2ua5001/ua5001 homozygous mutant fish compared to uninjected wild-type controls. (F–E) After 3dpf wild-type larvae injected with prp1 MO (f) show significant signs of necrosis and developmental abnormalities compared to uninjected and control injected larvae (d, e)

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab2-cdh1 IHC AB standard conditions Shield DEL plasma membrane
IHC AB + MO1-prnpb standard conditions Shield DEL plasma membrane
IHC prnpbua5003/ua5003; prnprs3ua5001/ua5001 standard conditions Shield DEL plasma membrane
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-prnpb standard conditions Shield protein localization process quality, normal
Protruding-mouth whole organism morphology, abnormal
Protruding-mouth whole organism necrotic, abnormal
prnpbua5003/ua5003; prnprs3ua5001/ua5001 standard conditions Shield protein localization process quality, normal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Prion