FIGURE

Fig. 10

ID

ZDB-FIG-210519-96

Publication

Tseng et al., 2021 - The role of Niemann-Pick type C2 in zebrafish embryonic development

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Fig. 10

(A) Whole-mount RNA in situ hybridization for notch3 and msx3 in 30 hpf Mnpc2^+/m and MZnpc2^m/m embryos. Expression of both notch3 and msx3 was observed mainly in the head area and was reduced in MZnpc2m/m embryos compared with Mnpc2^+/m embryos. The numbers of embryos examined showing the represented staining over the total numbers of embryos examined are indicated in each image (n=3 experiments). Scale bars: 200 μm (30 hpf); 100 μm (dorsal). (B) Magnifications of the otic vesicles shown in A. Both notch3 and msx3 were expressed along the lining of the otic vesicle in Mnpc2^+/m embryos. However, their expression was diminished around the otic vesicle in MZnpc2^m/m embryos (arrowheads). Scale bars: 100 μm.

Expression Data

Genes:	msx3 notch3
Fish:	npc2.1^y536/y536 (EKW) npc2.1^y536/+ (EKW)
Anatomical Terms:	brain otic vesicle trunk dorsal margin
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^y536/y536 (EKW)
Observed In:	brain otic vesicle trunk dorsal margin
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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